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Friday, January 24, 2014
what is HATU ?
HATU was first reported by Louis A. Carpino in 1993 as an efficient means of preparing active esters derived from 1-hydroxy-7-azabenzotriazole (HOAt). HATU can exist as either the uronium salt (O-form) or the less reactive iminium salt (N-form). HATU was initially reported as the O-form (1) using the original preparation reported by Carpino; however, X-ray crystallographic and NMR studies revealed the true structure of HATU to be the less reactive guanidinium isomer (2). It is, however, possible to obtain the uronium isomer by preparing HATU using KOAt in place of HOAt and working up the reaction mixture quickly to prevent isomerisation.
6-Chloropurine
The 6-Chloropurine, with its CAS NO 87-42-3, is a kind of light yellow crystalline powder. It has synonyms of 1H-Purine, 6-chloro- (9CI);6-Chloro-1H-purine;1H-Purine, 6-chloro-;SK 6048;Purine, 6-chloro-;X 47;6-chloro-5H-purine;6-CP;6-Chloro purine 98%;NSC-744 PVC Pigment Dispersion Chips. 6-Chloropurine should be stored in shady cool warehouse.
IUPAC Name: 6-chloro-7H-purine
InChI: InChI=1S/C5H3ClN4/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H,7,8,9,10)
InChIKey: ZKBQDFAWXLTYKS-UHFFFAOYSA-N
Canonical SMILES : C1=NC2=C(N1)C(=NC=N2)Cl
More about 6-Chloropurine
Thursday, January 23, 2014
About Imidocarb
Imidocarb is a diamidine of the carbanalide series of antiprotozoal compounds.
Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia (babesiosis) and other parasites.
Catalog No: 3B3-004889
CAS No: 55750-06-6
Molecular Formula: C19H20N6O.2C3H6O2
Molecular Weight: 496.57
Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia (babesiosis) and other parasites.
Catalog No: 3B3-004889
CAS No: 55750-06-6
Molecular Formula: C19H20N6O.2C3H6O2
Molecular Weight: 496.57
what is Erlotinib hydrochloride ?
Erlotinib hydrochloride is a drug used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).
Erlotinib is an EGFR inhibitor. The drug follows Iressa (gefitinib), which was the first drug of this type. Erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. By inhibiting the ATP, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.
CAS:183321-74-6
Molecular Formula:C22H23N3O4
Molecular Weight: 393.44g/mol
More about Erlotinib hydrochloride
Wednesday, January 22, 2014
the use of Azithromycin
Azithromycin prevents bacterial cells from manufacturing specific proteins necessary for their survival. It differs from other macrolides in its azalide structure. Azithromycin, as the dihydrate, is a white crystalline powder.Azithromycin is an antibiotic used in combination with other drugs as preventive to treat various bacterial infections, particularly of the sinuses, throat, and respiratory tract (such as bronchitis and pneumonia); infections of the ear; venereal disease due to chlamydial and chancroid infection; skin infections; and diarrhea associated with campylobacter and other bacteria that cause food poisoning. Also used to prevent and treat a tuberculosis-like disease known as Mycobacterium avium complex (MAC), which is common in people with advanced AIDS. Azithromycin is also used for treating cryptosporidiosis.
Azithromycin is used to treat many different infections, including acute otitis media, nonstreptococcal bacterial pharyngitis, gastrointestinal infections such as traveler's diarrhea, respiratory tract infections such as pneumonia, cellulitis, babesiosis, Bartonella infection, chancroid, cholera, donovanosis, leptospirosis, Lyme disease, malaria, Mycobacterium avium complex disease, Neisseria meningitis, pelvic inflammatory disease, pertussis, scrub typhus, toxoplasmosis, and salmonellosis. It is used to prevent bacterial endocarditis and some sexually transmitted infections.It is also effective against localized dental infections, uncomplicated skin and skin structure infections, urethritis and cervicitis and also genital ulcer disease. Azithromycin is used as a second line treatment for strep throat and for those allergic to penicillin. It has a similar antimicrobial spectrum to erythromycin, but is more effective against certain Gram-negative bacteria, in particular, Haemophilus influenzae (although it would not be the first choice of treatment in this infection). Azithromycin resistance has been described and is endemic in many areas. Long-term use in treating Staphylococcus aureus infections with azithromycin may increase bacterial resistance to this and other macrolide antibiotics.
CAS No.:83905-01-5
Molecular formula:C38H72N2O12
Molecular weight:748.984 g·mol
what is Berberine chloride hydrate ?
Berberine chloride hydrate occurs as yellow crystals or crystalline powder.It is odorless or has a faint,characteristic odor.It has a very bitter taste.It is sparingly soluble in methanol,sightly soluble in ethanol and very slightly soluble in water.
Berberine chloride hydrate is an alkaloid derived from Chinese goldthread, bark of cork tree and other plants. It can be also synthesized in artificial method. It is used as raw material to make preparations, which are usually administered the treatment of intestinal infections. Category Bitter stomachic, Antibacterial.
CAS No.:141433-60-5
Synonyms: 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride hydrate
Molecular formula: C20H18NO4.Cl.H2O
Molecular weight: 389.83
More about Berberine chloride hydrate
Tuesday, January 21, 2014
what is ZSM-5 ?
ZSM-5, Zeolite Socony Mobil–5, is an aluminosilicate zeolite belonging to the pentasil family of zeolites. Its chemical formula is NanAlnSi96–nO192·16H2O (0<n<27). Patented by Mobil Oil Company in 1975, it is widely used in the petroleum industry as a heterogeneous catalyst for hydrocarbon isomerization reactions.
ZSM-5 has a high silicon to aluminum ratio. Whenever an Al3+ cation replaces a Si4+ cation, an additional positive charge is required to keep the material charge-neutral. With proton (H+) as the cation, the material becomes very acidic. Thus the acidity is proportional to the Al content. The very regular 3-D structure and the acidity of ZSM-5 can be utilized for acid-catalyzed reactions such as hydrocarbon isomerization and the alkylation of hydrocarbons. One such reaction is the isomerization of meta-xylene to para-xylene. Within the pores of the ZSM-5 zeolite, para-xylene has a much higher diffusion coefficient than meta-xylene. When the isomerization reaction is allowed to occur within the pores of ZSM-5, para-xylene is able to traverse along the pores of the zeolite, diffusing out of the catalyst very quickly. This size-selectivity allows the isomerization reaction to occur quickly in high yield.
ZSM-5 has been used as a support material for catalysis. In one such example, copper is deposited on the zeolite and a stream of ethanol is passed through at temperatures of 240 to 320 °C as a vapour stream, which causes the ethanol to oxidize to acetaldehyde; two hydrogens are lost by the ethanol as hydrogen gas. It appears that the specific pore size of ZSM-5 is of benefit to this process, which also functions for other alcohols and oxidations. The copper is occasionally combined with other metals, such as chromium, to fine tune the diversity and specificity of the products, as there is likely to be more than one. Acetic acid is an example of one possible byproduct from hot copper oxidation.
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