Azoxymethane is a carcinogenic and neurotoxic chemical compound used in biological research.It is the oxide of azomethane.It is particularly effective in inducing colon carcinomas.
Azoxymethane is a potent carcinogen used to induce colon cancer in rats and mice. It has been used in studies evaluating efficacy of preventative treatment for azoxymethane-induced carcinogenesis.Azoxymethane is also commonly used to determine the chemopreventative effectiveness of particular foods such as undigestable sugars red meat, and green tea among others in rodent models. These rodent model results aid in the identification of possible preventative approaches to human colon cancer.
Changes or abnormalities in transforming growth factor beta (TGF-β) signaling are detected in tumors developed by mice treated with AOM. Treatment with azoxymethane activates intrinsic tyrosine kinase of EGF receptor while stimulating the synthesis of TGF-alpha.
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