The presentation of HOBt

1 - hydroxy benzotriazole (HOBT), ≥ 99% (HPLC)
Chinese name: 1 - hydroxy benzotriazole (HOBT), ≥ 99% (HPLC)
English name: NHydroxybenzotrizole
Synonyms: HOBT123Benzotriazol1ol.
Purity: ≥ 99%
CAS No.: 2592-95-2
Molecular formula: C6H5N3O
Molecular weight: 135.13 Performance description
Characters: white to off-white crystals
Physical parameters: melting point: 156 ~ 159 ° C (dec.)
Specifications
Purity: ≥ 99% (HPLC)
Loss on drying: ≤ 0.5%
Heavy metals: ≤ 20ppm
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Use instructions
DCC as a condensing agent in peptide synthesis inhibition racemic
Storage Transport: a cool dry place based on the amino components of a single N-alpha protected amino acids repeatedly added to the growth, synthesis of a step-by-step manner, usually from a synthesis of the C-terminal amino acid chain, followed by a single amino acid connected via the DCC, mixed carbon anhydride, or N-carboxy anhydride method. The Carbodiimide methods to connect the N-and C-protected amino acids using DCC coupling agent. Important connection reagents to Promote N to protect the freedom of amino acid carbon-based and C-protected amino acids, amino shrink, the formation of the peptide chain, while the output of N, N? / FONT>-dyaylcohercylurea byproduct. This method, however, because it led to the racemic side effects, or 5 (4H)-oxaylones and N-acylurea affected the formation of alkali exist. Fascinatingly, it is that these side effects can be minimized, if not completely eliminate. Method is to add the connection catalyst as HoSu or HoBT In addition, this method can be used for the synthesis of N-protected amino acids activated ester derivatives. Active ester in turn generated by spontaneous reaction with any other C-protected amino acids or peptides to form a new peptide.
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