1 The apparatus should be set up with the flask in a large container (such as a 14-qt. galvanized pail) to be used as a water bath, and under a well-ventilated hood, as both the bromine and bromoacetone are powerful irritants to the skin and mucous membranes.
2. It is necessary to warm the reaction mixture to this temperature to ensure a smooth reaction
3. It is not advisable to have too great an excess of bromine present at any time, as it sometimes reacts suddenly with great violence.
Bromoacetone has been prepared by the electrolysis of a mixture of acetone and hydrobromic acid, and by more orthodox methods of bromination: the addition of bromine to acetone dissolved in ten times its weight of water; the addition of bromine to acetone in which marble is suspended; the addition of bromine to acetone, water, and concentrated hydrochloric acid; and the introduction of bromine by means of a current of air into cold acetone.
A procedure similar to the one described above, except that the reaction mixture is illuminated with a powerful light, has been published.
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