Tuesday, December 31, 2013
what is Erythromycin ?
Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often prescribed for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including Mycoplasma and legionellosis. It was first marketed by Eli Lilly and Company, and it is today commonly known as EES (erythromycin ethylsuccinate, an ester prodrug that is commonly administered). It is also occasionally used as a prokinetic agent.
Erythromycin displays bacteriostatic activity or inhibits growth of bacteria, especially at higher concentrations, but the mechanism is not fully understood. By binding to the 50s subunit of the bacterial 70s rRNA complex, protein synthesis and subsequent structure and function processes critical for life or replication are inhibited. Erythromycin interferes with aminoacyl translocation, preventing the transfer of the tRNA bound at the A site of the rRNA complex to the P site of the rRNA complex. Without this translocation, the A site remains occupied and, thus, the addition of an incoming tRNA and its attached amino acid to the nascent polypeptide chain is inhibited. This interferes with the production of functionally useful proteins, which is the basis of this antimicrobial action.
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About Bestatin
Bestatin is an inhibitor of aminopeptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the aminopeptidase activity of LTA4 hydrolase with a Ki value of 201 nM. The IC50 value for inhibition of LTB4 synthesis is approximately 10 µM.
Formal Name N-(3R-amino-2S-hydroxy-1-oxo-4-phenylbutyl)-L-leucine, monohydrochloride
CAS Number 65391-42-6
Molecular Formula C16H24N2O4 · HCl
Formula Weight 344.8
Formulation A crystalline solid
Purity ≥99%
Stability 2 years
Storage -20°C
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Monday, December 30, 2013
About Amineptine Hydrochloride
Severe acne due to amineptine was first reported in 1988 , to name a few—simultaneously in the same issue of Annales de dermatologie et de vénéréologie and in 12 March 1988 of The Lancet. A year later, Dr Martin-Ortega and colleagues in Barcelona, Spain reported a case of "acneiform eruption" in a 54-year-old woman whose intake of amineptine was described as "excessive."[13] One year after that, Vexiau and colleagues reported six women, one of whom never admitted to using amineptine, getting severe acne concentrated in the face, back and thorax, the severity of which varied with the dosage. Most of them were treated unsuccessfully with isotretinoin (Accutane) for about 18 months; two of the three that discontinued amineptine experienced a reduction in cutaneous symptoms, with the least affected patient going into remission.
This can be seen as a general side effect of central dopamine enhancement, due to the inhibitory effect of dopamine on prolactin, with the subsequent increase in testosterone output, leading in turn to the same potential for acne as is typical of pubescents.
Amineptine Hydrochloride
CAS No.:30272-08-3
Synonyms: 7-[(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)amino]heptanoic acid hydrochloride
Molecular Formula: C22H27NO2.HCl
Molecular Weight: 373.92
Canonical SMILES: C1(c2c(CCc3c1cccc3)cccc2)[NH2+]CCCCCCC(O)=O.[ClH-]
what is Ceftriaxone ?
Ceftriaxone belongs to the family of antibiotics known as cephalosporins. It is used to prevent or treat certain infections caused by bacteria. It is given by injection only into a muscle or vein.
Ceftriaxone is often used to treat infections of the lung, urinary tract, skin, abdomen, bone, joint, and lining of the brain (meningitis), depending on the bacteria causing them. It can also be used to treat gonorrhea (a sexually transmitted infection).
Ceftriaxone is often used for the treatment of community-acquired or mild to moderate health care-associated pneumonia. It is also a choice drug for treatment of bacterial meningitis. In pediatrics, it is commonly used in febrile infants between 4 and 8 weeks of age who are admitted to the hospital to exclude sepsis. The dosage for acute ear infection in the very young is 50 mg
IM, one dose daily up to three days. It has also been used in the treatment of Lyme disease, typhoid fever, and gonorrhea.
Intravenous dosages may be adjusted for body mass in younger patients and is administered every 12–24 hours, at a dose that depends on the type and severity of the infection.
For the treatment of gonorrhea, a single intramuscular injection is usually given. According to the Journal of Family Practice, Volume 60, NO 12, December 2011, the intramuscular dose of Ceftriaxone Rocephin) has been increased from 125 mg IM to 250 mg IM due to increasing resistance of the gonococcal bacteria. It is also recommended that 100 mg of doxycycline be given orally at the same time for dual treatment. This takes care of treatment of underlying chlamydia, since treatment for chlamydia infection is also recommended. It must not be mixed or administered simultaneously (within 48 hours) with calcium-containing solutions or products for patients younger than 28 days old, even via different infusion lines .
CAS:104376-79-6
Molecular formula:C18H16N8Na2O7S3
Molecular weight:598.54
Ceftriaxone is often used to treat infections of the lung, urinary tract, skin, abdomen, bone, joint, and lining of the brain (meningitis), depending on the bacteria causing them. It can also be used to treat gonorrhea (a sexually transmitted infection).
Ceftriaxone is often used for the treatment of community-acquired or mild to moderate health care-associated pneumonia. It is also a choice drug for treatment of bacterial meningitis. In pediatrics, it is commonly used in febrile infants between 4 and 8 weeks of age who are admitted to the hospital to exclude sepsis. The dosage for acute ear infection in the very young is 50 mg
IM, one dose daily up to three days. It has also been used in the treatment of Lyme disease, typhoid fever, and gonorrhea.Intravenous dosages may be adjusted for body mass in younger patients and is administered every 12–24 hours, at a dose that depends on the type and severity of the infection.
For the treatment of gonorrhea, a single intramuscular injection is usually given. According to the Journal of Family Practice, Volume 60, NO 12, December 2011, the intramuscular dose of Ceftriaxone Rocephin) has been increased from 125 mg IM to 250 mg IM due to increasing resistance of the gonococcal bacteria. It is also recommended that 100 mg of doxycycline be given orally at the same time for dual treatment. This takes care of treatment of underlying chlamydia, since treatment for chlamydia infection is also recommended. It must not be mixed or administered simultaneously (within 48 hours) with calcium-containing solutions or products for patients younger than 28 days old, even via different infusion lines .
CAS:104376-79-6
Molecular formula:C18H16N8Na2O7S3
Molecular weight:598.54
Sunday, December 29, 2013
About 3Y yttria stabilized Nano-zro2 zirconium dioxide for ceramic
Product name : 3Y yttria stabilized Nano-zro2 zirconium dioxide for ceramic
CAS# : 1314-23-4
Property : small particle size of 20-40nm, 99.9% purity
Characteristic : Ceramics have good permeability and high bright cleanliness of surface when you add 3Y yttria stabilized Nano-zirconia to it.
Use range :
1.3Y yttria stabilized Nano-zro2 zirconium dioxide for ceramic can be used on high strength, high toughness, wear-resistant products: mill lining,
cutting tools, drawing dies, hot extrusion die, nozzles, valves, ball, pump parts, a variety of sliding parts, etc.;
2. The product can be used on functional ceramics, structural ceramics, in particular, electronic ceramics,
biological ceramics (such as: denture)
3. The product can be used in refractory materials: electronic ceramic bearing plate burning, melting glass,
metallurgy and metal materials;
4. After silane modified, when nano-ZrO2 particles are in the 3.0% addition level, you can significantly
improve the nano ZrO2/PMMA composite flexural strength.
We also produce 300 tons of 5Y yttria stabilized Nano-zirconia powder and particles and 300 tons of
8Y yttria stabilized Nano-zirconia powder and particles per year.
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what is Lithium hydroxide ?
Lithium hydroxide is an inorganic compound with the formula LiOH. It is a white hygroscopic crystalline material. It is soluble in water and slightly soluble in ethanol. It is available commercially in anhydrous form and as the monohydrate (LiOH.H2O), both of which are strong bases.
Lithium hydroxide is mainly consumed for the production of lithium greases. A popular lithium grease is lithium stearate, which is a general-purpose lubricating grease due to its high resistance to water and usefulness at both high and low temperatures.
Lithium hydroxide is used as a heat transfer medium and as a storage-battery electrolyte. It is also used in ceramics and some Portland cement formulations. Lithium hydroxide (isotopically enriched in lithium-7) is used to alkalize the reactor coolant in pressurized water reactors for corrosion control.
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Lithium hydroxide is mainly consumed for the production of lithium greases. A popular lithium grease is lithium stearate, which is a general-purpose lubricating grease due to its high resistance to water and usefulness at both high and low temperatures.
Lithium hydroxide is used as a heat transfer medium and as a storage-battery electrolyte. It is also used in ceramics and some Portland cement formulations. Lithium hydroxide (isotopically enriched in lithium-7) is used to alkalize the reactor coolant in pressurized water reactors for corrosion control.
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Friday, December 27, 2013
Naloxone hydrochloride dihydrate
Naloxone is an narcotic antagonist structurally related to oxymorphone (methyl group on the nitrogen is replaced by allylic group). It is derived from thebaine, a minor opiate alkaloid. The chemical name of The chemical name of naloxone is (-)-17-Allyl-4, 5a-epoxy-3,14-dihydroxymorphinan-6-one. Naloxone reverse opioid-induced respiratory depression, and as an adjunct in the treatment of sedation and hypotension. Naloxone blocks the action of alpha-agonists at opioid sites. It is a competitive antagonist for mu, kappa, delta, and sigma opioid receptors. Naloxone is specifically used to in emergency opioid overdose treatment. Structurally similar naltrexone is used for the long-term dependence treatment against opioid and alcohol addiction.Naloxone hydrochloride dihydrate is orthorhombic.
Product Categories:Opioids;Antagonists;Pharmacologicals;Enzyme Inhibitors;Enzyme Inhibitors by Type;
mp : 182 °C
storage temp: 2-8°C
solubility : ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.
form : powder
color: white to off-white
CAS : 1481-60-85
Molecular Formula : C19H26ClNO6
Formula Weight : 399.87
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