Naloxone hydrochloride dihydrate

Naloxone is an narcotic antagonist structurally related to oxymorphone (methyl group on the nitrogen is replaced by allylic group). It is derived from thebaine, a minor opiate alkaloid. The chemical name of The chemical name of naloxone is (-)-17-Allyl-4, 5a-epoxy-3,14-dihydroxymorphinan-6-one. Naloxone reverse opioid-induced respiratory depression, and as an adjunct in the treatment of sedation and hypotension. Naloxone blocks the action of alpha-agonists at opioid sites. It is a competitive antagonist for mu, kappa, delta, and sigma opioid receptors. Naloxone is specifically used to in emergency opioid overdose treatment. Structurally similar naltrexone is used for the long-term dependence treatment against opioid and alcohol addiction.Naloxone hydrochloride dihydrate  is orthorhombic.
Product Categories:Opioids;Antagonists;Pharmacologicals;Enzyme Inhibitors;Enzyme Inhibitors by Type;
mp : 182 °C
storage temp:  2-8°C
solubility : ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.
form : powder
color:  white to off-white

CAS : 1481-60-85
Molecular Formula : C19H26ClNO6
Formula Weight : 399.87