Enrofloxacin is a broad-spectrum bactericidal antibiotic. Although the mechanism of action is not well-understood, Enrofloxacin is effective against a broad spectrum of gram- positive and gram-negative bacteria including most species of the following: Pseudomonas aeruginosa, Klebsiella, E.coli., Enterobacter, Campylobacter, Shigella, Salmonella, Aeromonas, Haemophillus, Proteus, Yersinia, Serratia, Vibrio, Brucella, Chlamydia, Staphylocci.
Enrofloxacin is eliminated by both renal and hepatic metabolism. Animals with impaired kidney or liver function may need extra monitoring and dose adjustments to prevent excess drug accumulation.
Enrofloxacin is approved for use in dogs and cats. In dogs it may be given orally, intramuscularly or intra-venously. It is approved only for oral use in cats although there is published information regarding intramuscular use. One of the positive features of enrofloxacin is that it is well-absorbed orally and in many cases may be given once per day.
Fluroquinolones including enrofloxacin have been shown to cause articular cartilage abnormalities when the drug is given at high dose-levels. The age and breed of the patient should be considered when using enrofloxacin. Large and giant breeds may be more at risk because of a longer period of growth. Enrofloxacin has been shown to be safe in pregnant dogs and lactating dogs, however because of the problems with articular cartilage it should be avoided unless the benefits clearly outweigh the risk to the puppies. This work has not been repeated in cats.
CAS:93106-60-6
Specification:98min
Molecular Formula: C19H22FN3O3
Molecular Weight: 359.4 g/mol
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