Prostaglandin E1 (PGE1) known as Alprostadil ,is a prostaglandin. It is a drug used in the treatment of erectile dysfunction and has vasodilatory properties. In healthy humans, Prostaglandin E1 is biosynthesized "on demand" at its intended site of action from Dihomo-γ-linolenic_acid.
Alprostadil is also used in maintaining a patent ductus arteriosus in newborns. This is primarily useful when there is threat of premature closure of the ductus arteriosus in an infant with ductal-dependent congenital heart disease, including cyanotic lesions and acyanotic lesions (e.g., coarctation of the aorta, hypoplastic left heart syndrome, critical aortic stenosis, interrupted aortic arch).
Alprostadil is sold in the United States as urethral suppositories and in injectable form. The suppositories are sold under the brand name MUSE. The injectable forms are Edex and Caverject Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection will be needed.
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