The Introduction of ACTH (1-39) (human) (Corticotropin)

Adrenocorticotropic hormone abbreviated as ACTH. By the secretion of the anterior lobe of pituitary hormones. It has stimulated the development and function of the adrenal cortex function. Major role in the fascicular zone of adrenal cortex, stimulating glucocorticoid secretion.Corticotropin (adrenocor ticotropic hormore, ACTH) is secreted as a vertebrate pituitary peptide hormone that promotes the adrenal cortex tissue and the generation and secretion of corticosteroids. Generation and secretion of ACTH by the hypothalamus corticotropin-releasing factor (CRF) for direct control. Excessive secretion of corticosteroids, in turn, can affect the pituitary and hypothalamus, reduced their activities. It has stimulated the development and function of the adrenal cortex function. Major role in the fascicular zone of adrenal cortex, stimulating glucocorticoid secretion. By the injection of excess in vitro corticosteroids, ACTH secretion is suppressed, adrenal cortical atrophy. This is considered to be caused by "stress" state indispensable. ACTH by the adrenal cortex also has to regulate antibody production role. And auxin counterproductive.
From the shark, frog, ostrich, Preparation of the mammalian pituitary ACTH are thirty-nine peptide. Obvious difference is reflected in the molecular structure of C-terminal region (25 ~ 33). Terminal part of its ammonia (1 to 24 bits) of the amino acid sequence of a more consistent, and for the biological activity of the central area. Synthetic ACTH has been able to end zone with ammonia 24 peptide, which has presented the full ACTH activity. In addition to the distribution of ACTH in the pituitary, but is still found in the hypothalamus, adrenal medulla, intestine and placenta and other tissues. In the course of their biosynthesis, from opium-like peptide - MSH - corticotropin original (referred to as POMC) change from, ACTH itself but also as α-MSH (α-MSH) precursors (see Fig. .) Even in the lower invertebrates have similar peptide ACTH.
Of ACTH secretion is pulsatile and strain, the release of the frequency and amplitude associated with the circadian rhythm of the turn. The general trend is the early morning before awakening in the blood ACTH peak level was low at night when sleeping. Stress situations, such as burns, injury, poisoning, and attacks the body experiencing to alert reaction time, ACTH secretion is increased, then stimulate the release of adrenocorticotropic hormone, increase resistance. Medicine can be used for anti-inflammatory, anti-allergy.



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