Beta amyloid peptide precursor protein is in the brain inflammation in patients with AD spots-the main components of beta amyloid peptide metabolic precursor. The gene location in chromosome 21, the variable splicing can produce 10 transcript. Beta amyloid peptide precursor protein expression in widely almost all of the neurons and the neurons organization, with a long extracellular peptide chains, a single transmembrane area and a short intracellular area. Research has shown that it has the nerve nutrition, adjust the cell adhesion and inhibit serine protease and so on many kinds of biological activity. Existing data suggest that beta amyloid peptide precursor protein may be cell factor (or its analogs) receptor.
Beta amyloid protein (A-beta) is a way to alzheimer’s patients senile plaques in the brain found in one of the basic components. The protein may result from the body fight infection of natural immune system to the first line of defence. The latest research progress will allow alzheimer’s disease prevention and treatment of a breakthrough.
Beta amyloid protein (A-beta) is A way to alzheimer’s patients senile plaques in the brain found in one of the basic components. The protein may result from the body fight infection of natural immune system to the first line of defence. According to Massachusetts general hospital (MGH) of harvard medical school researchers describe, this beta amyloid protein is a kind of antimicrobial peptides. These small proteins from natural immune system, and has wide antimicrobial spectrum. Their report is to be published in the journal PLoS One. “We have been working wrong to think A-beta only some of the brain metabolic process by-products, but our research found that it is the direct components immune system.” Professor HMS Rudolph Tanzi said, “seems to stimulate the immune system in the brain of factors, and not only for the infection of exogenous injury and exciting, we already know that these factors can increase alzheimer’s disease risk, the same these factors result in the A-beta of excessive deposition. As all of the animals and plants, the common characteristics of natural immune system is resist invasion of the pathogen the first line of defense. The system can quickly mobilization of white blood cells, cells live element class and antimicrobial peptides to kill bacteria, viruses, fungi or even cancer cells. Antibodies and acquired immune product by blood brain barrier limit can’t go in the brain, and natural from the immune system of antibiotic resistance is in peptide central nervous system infection plays an important role.
A-beta is A nerve toxin, it in the brain for senile plaque is thought to be deposited alzheimer’s disease neurodegenerative become important characteristics. It consists of a kind of macromolecule pioneer starch proteins was related enzymes segmentation. The enzyme reaction can produce several different types of A-beta; Among them is usually A-beta 40 type and A-beta 42 type special tend to form toxic patches. Although people know A-beta can cause inflammation, but its biological activity has been regarded as A kind of harmful side effects. But the present studies have identified A-beta of the brain is the important biological components fight infection. The researchers found that the through A beta can inhibit 15 kinds of test in the growth of 8 kinds of pathogens. In the fight against the following seven kinds of infection of the pathogen include white chain beads bacterium and liszt bacteria genera and staph streptococcus and of A beta was in that have and have the same-37 LL or stronger antimicrobial function. Six of them all, A-beta 42 type than A-beta 40 type effect is better. In order to confirm alzheimer’s disease related A-beta protein has the same antimicrobial function, the researchers take alzheimer’s patients with their peers in the brain controls brain test inhibit the ability of bead chain bacterial growth. The results found that amyloid plaques exists mainly in the brain temporal lobe, important antimicrobial response only in alzheimer’s disease patients were obsered in the brain. The patient and not just the strength of the antibacterial response of A beta related content, and with an A-beta antibodies related activity. Another is found that the cerebellum tissue of the chain bead bacteria have not received suppression, because both alzheimer’s patients or controls cerebellum organization A-beta content are very low. The researchers hypothesized that due to natural immune system or continue to brief the central nervous system of the chronic infection may result in A-beta reaction of excess deposits. So know alzheimer’s disease risk factors: for example trauma, stroke or practical anesthetics, these can cause natural immune system activation and increase A-beta produce these factors can cause brain produces excessive dangerous inflammation. Except that the led directly to the genetic alzheimer’s disease of A rare gene can cause high level A-beta and type of generation, recently Tanzi and other researchers and found several in natural immune system play an important role in the genes. The researchers are working to through the swap brain natural immune system A-beta content that contains the genetic factors that people more easily than most people suffering from alzheimer’s disease that hypothesis. “Now we need to figure out what is what activates the natural immune system, especially as the growth of the age, and what is gene regulation the A-beta natural immune system in the role.” Harvard University assistant professor of neurology Moir said, “if we can find the kind of pathogen more likely to lead to A-beta peptide deposition, we can find the organization or control the reaction of the new method, for example the immune method.”
Beta amyloid protein (A-beta) is A way to alzheimer’s patients senile plaques in the brain found in one of the basic components. The protein may result from the body fight infection of natural immune system to the first line of defence. According to Massachusetts general hospital (MGH) of harvard medical school researchers describe, this beta amyloid protein is a kind of antimicrobial peptides. These small proteins from natural immune system, and has wide antimicrobial spectrum. Their report is to be published in the journal PLoS One. “We have been working wrong to think A-beta only some of the brain metabolic process by-products, but our research found that it is the direct components immune system.” Professor HMS Rudolph Tanzi said, “seems to stimulate the immune system in the brain of factors, and not only for the infection of exogenous injury and exciting, we already know that these factors can increase alzheimer’s disease risk, the same these factors result in the A-beta of excessive deposition. As all of the animals and plants, the common characteristics of natural immune system is resist invasion of the pathogen the first line of defense. The system can quickly mobilization of white blood cells, cells live element class and antimicrobial peptides to kill bacteria, viruses, fungi or even cancer cells. Antibodies and acquired immune product by blood brain barrier limit can’t go in the brain, and natural from the immune system of antibiotic resistance is in peptide central nervous system infection plays an important role.
A-beta is A nerve toxin, it in the brain for senile plaque is thought to be deposited alzheimer’s disease neurodegenerative become important characteristics. It consists of a kind of macromolecule pioneer starch proteins was related enzymes segmentation. The enzyme reaction can produce several different types of A-beta; Among them is usually A-beta 40 type and A-beta 42 type special tend to form toxic patches. Although people know A-beta can cause inflammation, but its biological activity has been regarded as A kind of harmful side effects. But the present studies have identified A-beta of the brain is the important biological components fight infection. The researchers found that the through A beta can inhibit 15 kinds of test in the growth of 8 kinds of pathogens. In the fight against the following seven kinds of infection of the pathogen include white chain beads bacterium and liszt bacteria genera and staph streptococcus and of A beta was in that have and have the same-37 LL or stronger antimicrobial function. Six of them all, A-beta 42 type than A-beta 40 type effect is better. In order to confirm alzheimer’s disease related A-beta protein has the same antimicrobial function, the researchers take alzheimer’s patients with their peers in the brain controls brain test inhibit the ability of bead chain bacterial growth. The results found that amyloid plaques exists mainly in the brain temporal lobe, important antimicrobial response only in alzheimer’s disease patients were obsered in the brain. The patient and not just the strength of the antibacterial response of A beta related content, and with an A-beta antibodies related activity. Another is found that the cerebellum tissue of the chain bead bacteria have not received suppression, because both alzheimer’s patients or controls cerebellum organization A-beta content are very low. The researchers hypothesized that due to natural immune system or continue to brief the central nervous system of the chronic infection may result in A-beta reaction of excess deposits. So know alzheimer’s disease risk factors: for example trauma, stroke or practical anesthetics, these can cause natural immune system activation and increase A-beta produce these factors can cause brain produces excessive dangerous inflammation. Except that the led directly to the genetic alzheimer’s disease of A rare gene can cause high level A-beta and type of generation, recently Tanzi and other researchers and found several in natural immune system play an important role in the genes. The researchers are working to through the swap brain natural immune system A-beta content that contains the genetic factors that people more easily than most people suffering from alzheimer’s disease that hypothesis. “Now we need to figure out what is what activates the natural immune system, especially as the growth of the age, and what is gene regulation the A-beta natural immune system in the role.” Harvard University assistant professor of neurology Moir said, “if we can find the kind of pathogen more likely to lead to A-beta peptide deposition, we can find the organization or control the reaction of the new method, for example the immune method.”
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