Friday, December 9, 2011

The Introduction of [Phe2, Nle4]-ACTH (1-24) (human)

English name: [Phe2, Nle4]-ACTH (1-24) H-SER-PHE-SER-NLE-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR -PRO-OHEnglish synonyms: [PHE2, NLE4]-ACTH (1-24); tetracosactrin [Phe2, Nle4]; ACTH (1-24), Phe (2)-Nle (4) -; SFS-NLE-EHFRWGKPVGKKRRPVKVYP; [PHE2, NLE4]-ACTH (1-24) (HUMAN); (PHE2 NLE4)-ADRENOCORTICOTROPIC HORMON &; (Phe2, Nle4)-ACTH (1-24) (human, bovine, rat); (PHE2, NLE4)-ADRENOCORTICOTROPIC HORMONE FRAGMENT 1-24); [PHE2, NLE4] ADRENOCORTICOTROPIC HORMONE (1-24) (HUMAN); [PHE2, NLE4]-ADRENOCORTICOTROPIC HORMONE FRAGMENT 1-24 HUMAN, RAT
Adrenocorticotropic hormone abbreviated as ACTH. By the secretion of the anterior lobe of pituitary hormones. It has stimulated the development and function of the adrenal cortex function. Major role in the fascicular zone of adrenal cortex, stimulating glucocorticoid secretion.Adrenocorticotropic hormone by the anterior pituitary secretion of the 39 peptides to stimulate the secretion of the adrenal cortex to induce the growth of the adrenal cortex.The secretion of ACTH process is pulsing and strain, the frequency and amplitude and release of alternating rhythm related day and night. The general trend is early morning awakening in the blood level before ACTH peak, the midnight when sleeping is low ebb. At the time of stress, such as burns, injury, poisoning, and meet a vigilance against and that body reaction, the secretion of ACTH increases, then stimulate the release of adrenal cortical hormone, promote resistance. Medicine can be used for the anti-inflammatory, allergy, etc.
Corticotropin (adrenocor ticotropic hormore, ACTH) is secreted as a vertebrate pituitary peptide hormone that promotes the adrenal cortex tissue and the generation and secretion of corticosteroids. Generation and secretion of ACTH by the hypothalamus corticotropin-releasing factor (CRF) for direct control. Excessive secretion of corticosteroids, in turn, can affect the pituitary and hypothalamus, reduced their activities. It has stimulated the development and function of the adrenal cortex function. Major role in the fascicular zone of adrenal cortex, stimulating glucocorticoid secretion. By the injection of excess in vitro corticosteroids, ACTH secretion is suppressed, adrenal cortical atrophy. This is considered to be caused by “stress” state indispensable. ACTH by the adrenal cortex also has to regulate antibody production role. And auxin counterproductive.


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